2021 Mercedes-Benz C300 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Compact Cars
The 2021 Mercedes-Benz C300 4matic gets 27 MPG combined — 23 city and 33 highway — in its most efficient configuration (2.0L · 4-cyl · Automatic 9-spd · 4-Wheel Drive).
City23 MPG
Highway33 MPG
$2,800Fuel cost / yr (EPA est.)
329 g/miCO₂
PremiumFuel
$-3,0005-yr fuel cost vs. average vehicle
6 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
90 ft³Passenger volume
Where it sits among compact cars (2021)
Compared with the 2020 model, the 2021 C300 4matic is +1 MPG better at its best.
FAQ
Is 27 MPG good for a compact cars like the 2021 C300 4matic?
The 2021 C300 4matic's 27 MPG combined is below the compact cars average of 27.3 MPG for 2021.
How much does it cost to fuel a 2021 C300 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $2,800 for the most efficient trim.
What is the city and highway MPG of the 2021 C300 4matic?
The most efficient trim is rated 23 MPG city and 33 MPG highway.