2022 Mercedes-Benz E450 4matic All-Terrain MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Station Wagons
The 2022 Mercedes-Benz E450 4matic All-Terrain gets 24 MPG combined — 21 city and 28 highway — in its most efficient configuration (3.0L · 6-cyl · Automatic 9-spd · 4-Wheel Drive · Hybrid).
City21 MPG
Highway28 MPG
$3,150Fuel cost / yr (EPA est.)
368 g/miCO₂
PremiumFuel
$-4,7505-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
35 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2022)
FAQ
Does the 2022 E450 4matic All-Terrain get good gas mileage for its class?
The 2022 E450 4matic All-Terrain's 24 MPG combined is below the sedans average of 33.2 MPG for 2022.
How much does it cost to fuel a 2022 E450 4matic All-Terrain per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,150 for the most efficient trim.
What is the city and highway MPG of the 2022 E450 4matic All-Terrain?
The most efficient trim is rated 21 MPG city and 28 MPG highway.