2020 Mercedes-Benz E450 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2020 Mercedes-Benz E450 4matic gets 23 MPG combined — 20 city and 28 highway — in its most efficient configuration (3.0L · 6-cyl · Automatic 9-spd · 4-Wheel Drive).
City20 MPG
Highway28 MPG
$3,300Fuel cost / yr (EPA est.)
392 g/miCO₂
PremiumFuel
$-5,5005-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2020)
Every 2020 E450 4matic trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.0L · 6-cyl · Automatic 9-spd · 4-Wheel Drive | 20 | 28 | 23 | $3,300 |
| 3.0L · 6-cyl · Automatic 9-spd · 4-Wheel Drive | 19 | 26 | 22 | $3,450 |
FAQ
How does the 2020 E450 4matic's fuel economy compare to other sedans?
The 2020 E450 4matic's 23 MPG combined is below the sedans average of 30.5 MPG for 2020.
How much does it cost to fuel a 2020 E450 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,300 for the most efficient trim.
What is the city and highway MPG of the 2020 E450 4matic?
The most efficient trim is rated 20 MPG city and 28 MPG highway.