2023 Mercedes-Benz E450 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2023 Mercedes-Benz E450 4matic gets 26 MPG combined — 23 city and 31 highway — in its most efficient configuration (3.0L · 6-cyl · Automatic 9-spd · All-Wheel Drive · Hybrid).
City23 MPG
Highway31 MPG
$2,900Fuel cost / yr (EPA est.)
343 g/miCO₂
PremiumFuel
$-3,5005-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2023)
Compared with the 2022 model, the 2023 E450 4matic is +1 MPG better at its best.
FAQ
How does the 2023 E450 4matic's fuel economy compare to other sedans?
The 2023 E450 4matic's 26 MPG combined is below the sedans average of 36.6 MPG for 2023.
How much does it cost to fuel a 2023 E450 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $2,900 for the most efficient trim.
What is the city and highway MPG of the 2023 E450 4matic?
The most efficient trim is rated 23 MPG city and 31 MPG highway.