2024 Mercedes-Benz E450 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2024 Mercedes-Benz E450 4matic gets 25 MPG combined — 22 city and 31 highway — in its most efficient configuration (3.0L · 6-cyl · Automatic 9-spd · All-Wheel Drive · Hybrid).
City22 MPG
Highway31 MPG
$3,050Fuel cost / yr (EPA est.)
355 g/miCO₂
PremiumFuel
$-4,2505-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
100 ft³Passenger volume
Where it sits among sedans (2024)
Compared with the 2023 model, the 2024 E450 4matic is -1 MPG worse at its best.
FAQ
How does the 2024 E450 4matic's fuel economy compare to other sedans?
The 2024 E450 4matic's 25 MPG combined is below the sedans average of 45.5 MPG for 2024.
How much does it cost to fuel a 2024 E450 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,050 for the most efficient trim.
What is the city and highway MPG of the 2024 E450 4matic?
The most efficient trim is rated 22 MPG city and 31 MPG highway.