2021 Mercedes-Benz S500 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Large Cars
The 2021 Mercedes-Benz S500 4matic gets 24 MPG combined — 20 city and 29 highway — in its most efficient configuration (3.0L · 6-cyl · Automatic 9-spd · 4-Wheel Drive · Hybrid).
City20 MPG
Highway29 MPG
$3,150Fuel cost / yr (EPA est.)
372 g/miCO₂
PremiumFuel
$-4,7505-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
112 ft³Passenger volume
Where it sits among sedans (2021)
FAQ
Is 24 MPG good for a sedans like the 2021 S500 4matic?
The 2021 S500 4matic's 24 MPG combined is below the sedans average of 30.2 MPG for 2021.
How much does it cost to fuel a 2021 S500 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,150 for the most efficient trim.
What is the city and highway MPG of the 2021 S500 4matic?
The most efficient trim is rated 20 MPG city and 29 MPG highway.