2021 Mercedes-Benz S580 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Large Cars
The 2021 Mercedes-Benz S580 4matic gets 20 MPG combined — 17 city and 25 highway — in its most efficient configuration (4.0L · 8-cyl · Automatic 9-spd · 4-Wheel Drive · Hybrid).
City17 MPG
Highway25 MPG
$3,800Fuel cost / yr (EPA est.)
452 g/miCO₂
PremiumFuel
$-8,0005-yr fuel cost vs. average vehicle
4 / 10EPA Fuel Economy & GHG score
14 ft³Cargo volume
107 ft³Passenger volume
Where it sits among sedans (2021)
FAQ
Is 20 MPG good for a sedans like the 2021 S580 4matic?
The 2021 S580 4matic's 20 MPG combined is below the sedans average of 30.2 MPG for 2021.
How much does it cost to fuel a 2021 S580 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,800 for the most efficient trim.
What is the city and highway MPG of the 2021 S580 4matic?
The most efficient trim is rated 17 MPG city and 25 MPG highway.