2024 Mercedes-Benz S580 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Large Cars
The 2024 Mercedes-Benz S580 4matic gets 21 MPG combined — 18 city and 27 highway — in its most efficient configuration (4.0L · 8-cyl · Automatic 9-spd · All-Wheel Drive · Hybrid).
City18 MPG
Highway27 MPG
$3,600Fuel cost / yr (EPA est.)
418 g/miCO₂
PremiumFuel
$-7,0005-yr fuel cost vs. average vehicle
4 / 10EPA Fuel Economy & GHG score
14 ft³Cargo volume
107 ft³Passenger volume
Where it sits among sedans (2024)
Compared with the 2023 model, the 2024 S580 4matic is +2 MPG better at its best.
FAQ
Is 21 MPG good for a sedans like the 2024 S580 4matic?
The 2024 S580 4matic's 21 MPG combined is below the sedans average of 45.5 MPG for 2024.
How much does it cost to fuel a 2024 S580 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,600 for the most efficient trim.
What is the city and highway MPG of the 2024 S580 4matic?
The most efficient trim is rated 18 MPG city and 27 MPG highway.