2025 Mercedes-Benz S580 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Large Cars
The 2025 Mercedes-Benz S580 4matic gets 20 MPG combined — 17 city and 25 highway — in its most efficient configuration (4.0L · 8-cyl · Automatic 9-spd · All-Wheel Drive · Hybrid).
City17 MPG
Highway25 MPG
$3,800Fuel cost / yr (EPA est.)
448 g/miCO₂
PremiumFuel
$-8,0005-yr fuel cost vs. average vehicle
4 / 10EPA Fuel Economy & GHG score
14 ft³Cargo volume
107 ft³Passenger volume
Where it sits among sedans (2025)
Compared with the 2024 model, the 2025 S580 4matic is -1 MPG worse at its best.
FAQ
Is 20 MPG good for a sedans like the 2025 S580 4matic?
The 2025 S580 4matic's 20 MPG combined is below the sedans average of 48.9 MPG for 2025.
How much does it cost to fuel a 2025 S580 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,800 for the most efficient trim.
What is the city and highway MPG of the 2025 S580 4matic?
The most efficient trim is rated 17 MPG city and 25 MPG highway.