2006 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2006 Mercedes-Benz E350 4matic gets 19 MPG combined — 16 city and 23 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive).
City16 MPG
Highway23 MPG
$4,000Fuel cost / yr (EPA est.)
468 g/miCO₂
PremiumFuel
$-9,0005-yr fuel cost vs. average vehicle
14 ft³Cargo volume
97 ft³Passenger volume
Where it sits among sedans (2006)
Every 2006 E350 4matic trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive | 16 | 23 | 19 | $4,000 |
| 3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive | 16 | 22 | 18 | $4,200 |
FAQ
Is 19 MPG good for a sedans like the 2006 E350 4matic?
The 2006 E350 4matic's 19 MPG combined is below the sedans average of 19.6 MPG for 2006.
How much does it cost to fuel a 2006 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $4,000 for the most efficient trim.
What is the city and highway MPG of the 2006 E350 4matic?
The most efficient trim is rated 16 MPG city and 23 MPG highway.