2016 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2016 Mercedes-Benz E350 4matic gets 23 MPG combined — 20 city and 27 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive · FFV).
City20 MPG
Highway27 MPG
$3,300Fuel cost / yr (EPA est.)
384 g/miCO₂
Premium or E85Fuel
$-5,5005-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2016)
Every 2016 E350 4matic trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive · FFV | 20 | 27 | 23 | $3,300 |
| 3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive | 20 | 27 | 23 | $3,300 |
| 3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive | 20 | 26 | 22 | $3,450 |
FAQ
Is 23 MPG good for a sedans like the 2016 E350 4matic?
The 2016 E350 4matic's 23 MPG combined is below the sedans average of 27.7 MPG for 2016.
How much does it cost to fuel a 2016 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,300 for the most efficient trim.
What is the city and highway MPG of the 2016 E350 4matic?
The most efficient trim is rated 20 MPG city and 27 MPG highway.