2012 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2012 Mercedes-Benz E350 4matic gets 22 MPG combined — 19 city and 28 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive).
City19 MPG
Highway28 MPG
$3,450Fuel cost / yr (EPA est.)
404 g/miCO₂
PremiumFuel
$-6,2505-yr fuel cost vs. average vehicle
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2012)
Compared with the 2011 model, the 2012 E350 4matic is +3 MPG better at its best.
Every 2012 E350 4matic trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive | 19 | 28 | 22 | $3,450 |
| 3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive | 19 | 27 | 22 | $3,450 |
FAQ
Is 22 MPG good for a sedans like the 2012 E350 4matic?
The 2012 E350 4matic's 22 MPG combined is below the sedans average of 22.9 MPG for 2012.
How much does it cost to fuel a 2012 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,450 for the most efficient trim.
What is the city and highway MPG of the 2012 E350 4matic?
The most efficient trim is rated 19 MPG city and 28 MPG highway.