2020 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2020 Mercedes-Benz E350 4matic gets 25 MPG combined — 22 city and 30 highway — in its most efficient configuration (2.0L · 4-cyl · Automatic 9-spd · 4-Wheel Drive).
City22 MPG
Highway30 MPG
$3,050Fuel cost / yr (EPA est.)
354 g/miCO₂
PremiumFuel
$-4,2505-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2020)
FAQ
Is 25 MPG good for a sedans like the 2020 E350 4matic?
The 2020 E350 4matic's 25 MPG combined is below the sedans average of 30.5 MPG for 2020.
How much does it cost to fuel a 2020 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,050 for the most efficient trim.
What is the city and highway MPG of the 2020 E350 4matic?
The most efficient trim is rated 22 MPG city and 30 MPG highway.