2010 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2010 Mercedes-Benz E350 4matic gets 19 MPG combined — 17 city and 24 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · 4-Wheel Drive).
City17 MPG
Highway24 MPG
$4,000Fuel cost / yr (EPA est.)
468 g/miCO₂
PremiumFuel
$-9,0005-yr fuel cost vs. average vehicle
14 ft³Cargo volume
97 ft³Passenger volume
Where it sits among sedans (2010)
Compared with the 2009 model, the 2010 E350 4matic is +1 MPG better at its best.
FAQ
Is 19 MPG good for a sedans like the 2010 E350 4matic?
The 2010 E350 4matic's 19 MPG combined is below the sedans average of 20.9 MPG for 2010.
How much does it cost to fuel a 2010 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $4,000 for the most efficient trim.
What is the city and highway MPG of the 2010 E350 4matic?
The most efficient trim is rated 17 MPG city and 24 MPG highway.