2025 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2025 Mercedes-Benz E350 4matic gets 27 MPG combined — 24 city and 33 highway — in its most efficient configuration (2.0L · 4-cyl · Automatic 9-spd · All-Wheel Drive · Hybrid).
City24 MPG
Highway33 MPG
$2,800Fuel cost / yr (EPA est.)
327 g/miCO₂
PremiumFuel
$-3,0005-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
100 ft³Passenger volume
Where it sits among sedans (2025)
FAQ
Is 27 MPG good for a sedans like the 2025 E350 4matic?
The 2025 E350 4matic's 27 MPG combined is below the sedans average of 48.9 MPG for 2025.
How much does it cost to fuel a 2025 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $2,800 for the most efficient trim.
What is the city and highway MPG of the 2025 E350 4matic?
The most efficient trim is rated 24 MPG city and 33 MPG highway.