2009 Mercedes-Benz E350 4matic MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2009 Mercedes-Benz E350 4matic gets 18 MPG combined — 16 city and 22 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive).
City16 MPG
Highway22 MPG
$4,200Fuel cost / yr (EPA est.)
494 g/miCO₂
PremiumFuel
$-10,0005-yr fuel cost vs. average vehicle
14 ft³Cargo volume
97 ft³Passenger volume
Where it sits among sedans (2009)
Every 2009 E350 4matic trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive | 16 | 22 | 18 | $4,200 |
| 3.5L · 6-cyl · Automatic 5-spd · 4-Wheel or All-Wheel Drive | 16 | 21 | 18 | $4,200 |
FAQ
Is 18 MPG good for a sedans like the 2009 E350 4matic?
The 2009 E350 4matic's 18 MPG combined is below the sedans average of 20.3 MPG for 2009.
How much does it cost to fuel a 2009 E350 4matic per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $4,200 for the most efficient trim.
What is the city and highway MPG of the 2009 E350 4matic?
The most efficient trim is rated 16 MPG city and 22 MPG highway.