2006 Mercedes-Benz E350 MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2006 Mercedes-Benz E350 gets 20 MPG combined — 17 city and 25 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive).
City17 MPG
Highway25 MPG
$3,800Fuel cost / yr (EPA est.)
444 g/miCO₂
PremiumFuel
$-8,0005-yr fuel cost vs. average vehicle
14 ft³Cargo volume
97 ft³Passenger volume
Where it sits among sedans (2006)
Every 2006 E350 trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive | 17 | 25 | 20 | $3,800 |
| 3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive | 16 | 24 | 19 | $4,000 |
FAQ
Does the 2006 E350 get good gas mileage for its class?
The 2006 E350's 20 MPG combined is above the sedans average of 19.6 MPG for 2006.
How much does it cost to fuel a 2006 E350 per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,800 for the most efficient trim.
What is the city and highway MPG of the 2006 E350?
The most efficient trim is rated 17 MPG city and 25 MPG highway.