2012 Mercedes-Benz E350 MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2012 Mercedes-Benz E350 gets 23 MPG combined — 20 city and 30 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive).
City20 MPG
Highway30 MPG
$3,300Fuel cost / yr (EPA est.)
386 g/miCO₂
PremiumFuel
$-5,5005-yr fuel cost vs. average vehicle
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2012)
Compared with the 2011 model, the 2012 E350 is +3 MPG better at its best.
FAQ
Does the 2012 E350 get good gas mileage for its class?
The 2012 E350's 23 MPG combined is above the sedans average of 22.9 MPG for 2012.
How much does it cost to fuel a 2012 E350 per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,300 for the most efficient trim.
What is the city and highway MPG of the 2012 E350?
The most efficient trim is rated 20 MPG city and 30 MPG highway.