2015 Mercedes-Benz E350 MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2015 Mercedes-Benz E350 gets 23 MPG combined — 20 city and 28 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive).
City20 MPG
Highway28 MPG
$3,300Fuel cost / yr (EPA est.)
379 g/miCO₂
PremiumFuel
$-5,5005-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2015)
Compared with the 2014 model, the 2015 E350 is -1 MPG worse at its best.
Every 2015 E350 trim
| Configuration | City | Hwy | Comb. | $/yr |
|---|---|---|---|---|
| 3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive | 20 | 28 | 23 | $3,300 |
| 3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive · FFV | 20 | 28 | 23 | $3,300 |
FAQ
Does the 2015 E350 get good gas mileage for its class?
The 2015 E350's 23 MPG combined is below the sedans average of 25.7 MPG for 2015.
How much does it cost to fuel a 2015 E350 per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,300 for the most efficient trim.
What is the city and highway MPG of the 2015 E350?
The most efficient trim is rated 20 MPG city and 28 MPG highway.