2010 Mercedes-Benz E350 MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2010 Mercedes-Benz E350 gets 21 MPG combined — 18 city and 26 highway — in its most efficient configuration (3.5L · 6-cyl · Automatic 7-spd · Rear-Wheel Drive).
City18 MPG
Highway26 MPG
$3,600Fuel cost / yr (EPA est.)
423 g/miCO₂
PremiumFuel
$-7,0005-yr fuel cost vs. average vehicle
14 ft³Cargo volume
97 ft³Passenger volume
Where it sits among sedans (2010)
Compared with the 2009 model, the 2010 E350 is +2 MPG better at its best.
FAQ
Does the 2010 E350 get good gas mileage for its class?
The 2010 E350's 21 MPG combined is above the sedans average of 20.9 MPG for 2010.
How much does it cost to fuel a 2010 E350 per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,600 for the most efficient trim.
What is the city and highway MPG of the 2010 E350?
The most efficient trim is rated 18 MPG city and 26 MPG highway.