2021 Mercedes-Benz E350 MPG
EPA-rated · verified snapshot 2026-08-30 · Midsize Cars
The 2021 Mercedes-Benz E350 gets 25 MPG combined — 22 city and 31 highway — in its most efficient configuration (2.0L · 4-cyl · Automatic 9-spd · Rear-Wheel Drive).
City22 MPG
Highway31 MPG
$3,050Fuel cost / yr (EPA est.)
349 g/miCO₂
PremiumFuel
$-4,2505-yr fuel cost vs. average vehicle
5 / 10EPA Fuel Economy & GHG score
13 ft³Cargo volume
98 ft³Passenger volume
Where it sits among sedans (2021)
Compared with the 2020 model, the 2021 E350 is -1 MPG worse at its best.
FAQ
Does the 2021 E350 get good gas mileage for its class?
The 2021 E350's 25 MPG combined is below the sedans average of 30.2 MPG for 2021.
How much does it cost to fuel a 2021 E350 per year?
Based on EPA assumptions (15,000 miles/year), estimated annual fuel cost is $3,050 for the most efficient trim.
What is the city and highway MPG of the 2021 E350?
The most efficient trim is rated 22 MPG city and 31 MPG highway.